Need(le)less confusion

Needleless Injection System

Even though oral route is the most preferred one, certain conditions necessitate the use of parenteral dosage form. But this route being invasive, is considered as non-patient compliant. Thus, there came a need for a more patient compliant system which led to the development of needleless injection technology. This review intends to throw light on the basic mechanisms by which this technology w...

Upward Needleless Electrospinning of Nanofibers

Polyacrylonitrile (PAN) nanofibers were prepared by a needleless electrospinning method using three rotating fiber generators, cylinder, disc and coil. The effects of the spinneret shape on the electrospinning process and resultant fiber morphology were examined. The disc spinneret needed the lowest voltage to initiate fiber formation, followed by the coil and cylinder. Compared to cylinder, th...

Needleless Electrospinning: Developments and Performances

Confusion

Acetaminophen (paracetamol) plays a vital role in American health care, with in excess of 25 billion doses being used annually as a nonprescription medication. Over 200 million acetaminophen-containing prescriptions, usually in combination with an opioid, are dispensed annually. While acetaminophen is recognized as a safe and effective analgesic and antipyretic, it is also associated with signi...

Synthetic skin-permeable proteins enabling needleless immunization.

Protein drugs, because of their large size and hydrophilic nature, are normally precluded from effective delivery such as cell entry or tissue diffusion. Among the transport barriers, the skin poses a formidable challenge to proteins because of the impermeable stratum corneum. The existing techniques for percutaneous protein delivery must rely on sophisticated delivery systems, such as the use ...